On the contrary, clinical equipoise ensures that the hope was justifiedCharlie would be equally likely to benefit regardless of whether he enrolled in research. New Engl J Med 1987;317:1415. Clinical
On the contrary, clinical equipoise ensures that the hope was justifiedCharlie would be equally likely to benefit regardless of whether he enrolled in research. New Engl J Med 1987;317:1415. Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves assigning patients to different treatment. In its canonical formulation, clinical equipoise stipulates that a randomized controlled trial (RCT) is only ethical insofar as there exists, at the outset, a state of genuine uncertainty in the community of medical experts about the relative therapeutic merits of every arm in the trial. Clinical and personal equipoise exists when a clinician has no good basis for a choice between two or more care options or when one is truly uncertain about. There is, however, an ethical tension between. The fundamental point is that clinical equipoise does more for the physician-investigator and the research enterprise than restrict the domain of acceptable scientific comparisons. The ethics of clinical research requires equipoise -a state of genuine uncertainty on the part of the clinical investigator regarding the. At the same time, it would be emphasized that this preference is not shared by others. Equipoise as a means of managing uncertainty: personal, communal and proxy J Med Ethics 1996;223: 1359. In public health research, the justification for randomly assigning participants is based on clinical equipoise. A valid RCT requires that, until the study is complete, we do not know the arm of the trial in which Charlie is enrolled. Proponents of the RCTs argued that, despite the dramatic response rate in the early-phase studies, clinical equipoise could not be overturned on the basis of a surrogate endpoint (i.e., tumor response rate) alone.